4-Fluoroaniline → HCID 86638132, compound

HRID 1931430Notes

Reaction equation

HRID 1931430 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[F:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:25][C:26]1[CH:32]=[CH:31][C:29]([NH:30][C:22](=[O:24])[CH2:21][NH:20][C:17]2[S:18][CH:19]=[C:15]([C:12]3[CH:11]=[CH:10][C:9]([F:8])=[CH:14][CH:13]=3)[N:16]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 44184931[4-(4-Fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt

Product 1

HCID 86638132HCID 86638132, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 200 mg (0.55 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt and 121.3 mg (1.1 mmol) of 4-fluoroaniline. Yield: 13 mg.

Sources & evidence

ORD record
ord-6c9b7b3eb58f48c392146cca2f824211
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

Loading…