2-Aminopyridine → 2-[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-N-(pyridin-2-yl)-acetamide trifluoroacetic acid salt

HRID 1931438Notes

Reaction equation

HRID 1931438 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=1.[NH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)=[O:25])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 104392-AminopyridineHCID 68540719[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt

Product 1

HCID 685401862-[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-N-(pyridin-2-yl)-acetamide trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 90 mg (0.25 mmol) of [6-(2-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt and 28.1 mg (0.3 mmol) of 2-aminopyridine. Yield: 28 mg.

Sources & evidence

ORD record
ord-c3002d85bc2c49b7b435ffd2ad8cfb01
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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