4-Fluoroaniline → N-(4-Fluoro-phenyl)-2-[6-(4-fluoro-phenyl)-pyridin-3-yloxy]-acetamide trifluoroacetic acid salt
Reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[F:26][C:27]1[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:26][C:27]1[CH:33]=[CH:32][C:30]([NH:31][C:23](=[O:25])[CH2:22][O:21][C:18]2[CH:19]=[N:20][C:15]([C:12]3[CH:11]=[CH:10][C:9]([F:8])=[CH:14][CH:13]=3)=[CH:16][CH:17]=2)=[CH:29][CH:28]=1Participants
3
Procedure
The title compound was prepared analogously as described in Example 30(d) from 95 mg (0.26 mmol) of [6-(4-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt and 43.8 mg (0.39 mmol) of 4-fluoroaniline. Yield: 31 mg.
Sources & evidence
- ORD record
- ord-882c0b95d1074e4db21d7382cb411053
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08188291B2
Reaction notes
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