2-Fluoroaniline → N-(2-Fluoro-phenyl)-2-[6-(4-fluoro-phenyl)-pyridin-3-yloxy]-acetamide trifluoroacetic acid salt

HRID 1931463Notes

Reaction equation

HRID 1931463 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[F:26][C:27]1[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=1[NH2:29]>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:26][C:27]1[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=1[NH:29][C:23](=[O:25])[CH2:22][O:21][C:18]1[CH:19]=[N:20][C:15]([C:12]2[CH:11]=[CH:10][C:9]([F:8])=[CH:14][CH:13]=2)=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 95842-FluoroanilineHCID 68534898[6-(4-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt

Product 1

HCID 68536746N-(2-Fluoro-phenyl)-2-[6-(4-fluoro-phenyl)-pyridin-3-yloxy]-acetamide trifluoroacetic acid salt

Procedure

The title compound was prepared analogously as described in Example 30(d) from 95 mg (0.26 mmol) of [6-(4-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt and 43.8 mg (0.39 mmol) of 2-fluoroaniline. Yield: 9 mg.

Sources & evidence

ORD record
ord-a6d20377050d4d58a88ef7b74770812a
Source dataset
uspto-grants-2012_05
Patent number
US08188291B2

Reaction notes

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