(R)-(-)-1-Aminoindan → HCID 44217629, compound

HRID 1931477Notes

Reaction equation

HRID 1931477 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([OH:12])[CH:8]=2)[N:3]=1.[NH2:13][C@H:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1.Br.Br[CH2:25][C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1>>[C@H:14]1([NH:13][C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([O:12][CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH:8]=3)[N:3]=2)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 2733933(R)-(-)-1-AminoindanHCID 127070373-(Bromomethyl)pyridine hydrobromideHCID 221325772-Chloroquinolin-6-ol

Product 1

HCID 44217629HCID 44217629, compound

Procedure

The title compound, MS: m/e=368.6 (M+H+), was prepared in accordance with the general method of example 1 from 2-chloro-6-hydroxy-quinoline, (R)-1-aminoindane and 3-(brommethyl)pyridine-HBr.

Sources & evidence

ORD record
ord-0edb069fe9264211acbab5c50417bda0
Source dataset
uspto-grants-2012_05
Patent number
US08188284B2

Reaction notes

Loading…