HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1931482Generated: November 3, 2026
(R)-(-)-1-Aminoindan → (6-nitro-quinolin-2-yl)-(R)-indan-1-yl-amine
https://huagongshe.com/reaction/1931482
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (R)-(-)-1-Aminoindan | HCID 2733933 | — |
| Reactant | 2-Chloro-6-nitroquinoline | HCID 10921723 | — |
| Product | (6-nitro-quinolin-2-yl)-(R)-indan-1-yl-amine | HCID 57860965 | 47% |
Reaction Steps
A stirred mixture of 2-chloro-6-nitro-quinoline (2.2 g, 11 mmol) and (R)-1-aminoindane (2.8 g, 21 mmol) was heated in a sealed tube for 20 h at 125° C. Purification by flash chromatography on silica gel (ethyl acetate/heptane 0:1=>3:7) yielded (6-nitro-quinolin-2-yl)-(R)-indan-1-yl-amine as a brownish solid (1.5 g, 47%), MS 306.5 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08188284B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-431c548139114268a2a4b336e057ab87 |
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| Source note | uspto-grants-2012_05 |
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