4-Fluorobenzenesulfonyl chloride → HCID 44217943, compound

Participants

Reaction Steps

(6-Amino-quinolin-2-yl)-(R)-indan-1-yl-amine (0.05 g, 0.18 mmol) and 4-fluoro-benzenesulfonyl chloride (0.035 g, 0.18 mmol) were dissolved in pyridine (1 mL). The reaction mixture was stirred for 16 h at ambient temperature. Saturated sodium bicarbonate solution was added then and the aqueous phase extracted with ethyl acetate (3×10 mL). The combined organic phases were dried over sodium sulfate, filtered and the filtrate was evaporated. The residual oil was subjected to column chromatography (silica gel, heptane, ethyl acetate; 9:1=>1:1) to yield the title compound as a brown solid (5 mg, 6%); MS 434.7 [(M+H)+].

Provenance & Evidence