Benzeneacetic acid, 2-fluoro- → HCID 44218725, compound

Participants

Reaction Steps

(R)—N2-indan-1-yl-quinoline-2,6-diamine (0.05 g, 0.18 mmol), ethyldiisopropylamine (0.068 mL, 0.4 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC-HCl, 0.038 mg, 0.2 mmol), 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (HOBt, 0.027 mg, 0.2 mmol) and 2-fluorophenyl acetic acid (0.031 mg, 0.2 mmol) were dissolved in tetrahydrofurane (3.0 mL). The reaction mixture was stirred at ambient temperature for 3 h. Then it was diluted with water and extracted with ethyl acetate (3×). The combined organic phases were dried on sodium sulfate and evaporated. The crude product was purified by column chromatography (silica gel, heptane, ethyl acetate 4:1/1:1). The title compound (0.025 g, 33%) was obtained as an off-white solid; MS: m/e=412.6 (M+H+).

Provenance & Evidence