Ammonia → HCID 178513783, compound

HRID 1931543Notes

Reaction equation

HRID 1931543 reaction equation
[Br:1][C:2]1[N:6]=[C:5]([C:7]([O:9]C)=O)[NH:4][N:3]=1.CO.[NH3:13]>>[Br:1][C:2]1[N:6]=[C:5]([C:7]([NH2:13])=[O:9])[NH:4][N:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 178499058HCID 178499058, compound

Product 1

HCID 178513783HCID 178513783, compound

Procedure

A solution of methyl 3-bromo-1H-1,2,4-triazole-5-carboxylate from Step 1 (250 mg, 1.21 mmol) in 7M ammonia in methanol (4 mL, 28 mmol) was heated at 125° C. under microwave conditions for 40 minutes. The reaction solution was concentrated under vacuum to give the title compound as a solid.

Workup

  1. concentrationThe reaction solution was concentrated under vacuum

Sources & evidence

ORD record
ord-0f8191a827af41f19d59c00e2a936f2f
Source dataset
uspto-grants-2012_05
Patent number
US08188085B2

Reaction notes

Loading…