Methanol → HCID 178465744, compound

HRID 1931545Notes

Reaction equation

HRID 1931545 reaction equation
[CH2:1]([NH2:3])[CH3:2].CO.[NH:6]1[CH:10]=[N:9][C:8]([S:11](F)(=[O:13])=[O:12])=[N:7]1>C(O)(=O)C>[CH2:1]([NH:3][S:11]([C:8]1[N:9]=[CH:10][NH:6][N:7]=1)(=[O:13])=[O:12])[CH3:2]

Participants

5

Reactant 3

HCID 887MethanolHCID 6341EthylamineHCID 178527442HCID 178527442, compound

Product 1

HCID 178465744HCID 178465744, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidCatalyst

Procedure

To a solution of ethylamine in methanol (2 M, 2.4 mmol, 4.8 mmol) was added 1H-1,2,4-triazole-3-sulfonyl fluoride (200 mg, 1.18 mmol, J. Heterocycl. Chem. 1988, 25, 1857). After ten minutes the reaction was concentrated in vacuo to give a yellow oil. Ice-cold water (2-3 mL) was added and the resulting solution was sonicated for approximately one minute. Several drops of acetic acid were added which immediately caused precipitation of the title compound which was obtained as a white solid after filtration (57 mg).

Workup

  1. concentrationAfter ten minutes the reaction was concentrated in vacuo
  2. customto give a yellow oil
  3. customthe resulting solution was sonicated for approximately one minute
  4. customwhich immediately caused precipitation of the title compound which
  5. customwas obtained as a white solid
  6. filtrationafter filtration (57 mg)

Sources & evidence

ORD record
ord-49166569d7ff44dcb40d028812a44976
Source dataset
uspto-grants-2012_05
Patent number
US08188085B2

Reaction notes

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