反应详情

A solution of potassium hydroxide (85%; 824 mg, 12.5 mmol) in methanol (5 mL) was added to a refluxing solution of 1,2-difluoro-4-methanesulfonyl-benzene (2.00 g, 10.4 mmol) in methanol (10 mL) over 20 min. The resulting mixture was heated at reflux for 1 h and then cooled to room temperature. The solvent was evaporated, water was added, and the resulting precipitate was filtered off, washed with water, and dried in vacuo to give 2-fluoro-4-methanesulfonyl-1-methoxy-benzene (1.8 g, 85%) as a white solid which was used directly in the next step without purification.

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 1 h
3. customThe solvent was evaporated
4. additionwater was added
5. filtrationthe resulting precipitate was filtered off
6. washwashed with water
7. customdried in vacuo