Carbonate Ion → HCID 57544435, compound

Participants

Reaction Steps

A solution of 4-[4-(2-methyl-pyridin-3-yloxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (Example 92; 710 mg, 1.7 mmol) in 20% trifluoroacetic acid/dichloromethane (15 mL) was stirred at room temperature for 40 min, then the solvents were evaporated and the residue held under high vacuum to give a pale yellow thick oil. SiliaBond Carbonate (Silicycle, Quebec City, Canada; 4 equivalents) was added and the mixture was stirred slowly for 2.5 h, then filtered. The filtrate was evaporated and held under high vacuum to give 4-(2-methyl-pyridin-3-yloxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine (363 mg, 68%) as a white solid.

Provenance & Evidence