Trifluoroacetic acid → HCID 57965009, compound

Participants

Reaction Steps

[1-(1-Benzyl-piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-(2-fluoro-4-methanesulfonylphenyl)-amine was prepared according to General Procedure F by the reaction of 4-[4-(2-fluoro-4-methanesulfonyl-phenylamino)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (Example 1) with trifluoroacetic acid in dichloromethane followed by reaction with benzyl bromide (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA). 1H NMR (400 MHz, DMSO-d6) δ 1.87-1.90 (m, 2H), 2.13-2.24 (m, 4H), 2.93-2.97 (m, 2H), 3.54 (s, 2H), 4.67-4.72 (m, 1H), 7.25-7.35 (m, 5H), 7.78-7.81 (m, 1H), 7.88-7.91 (m, 1H), 8.20-8.24 (m, 1H), 8.38-8.41 (m, 2H), 11.71 (s, 1H). Mass spectrum MH+=481.

Provenance & Evidence