2-Fluorophenol → HCID 57964891, compound

Participants

Reaction Steps

4-[4-(2-Fluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure A by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 2-fluorophenol (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in acetonitrile. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.97-2.07 (m, 4H), 2.97-3.07 (m, 2H), 4.05-4.12 (m, 2H), 4.98-5.05 (m, 1H), 7.31-7.50 (m, 4H), 8.38 (s, 1H), 8.55 (s, 1H). Mass spectrum MH+=414.

Provenance & Evidence