3-Fluorophenol → HCID 57965049, compound

Participants

Reaction Steps

4-[4-(3-Fluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure B by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 3-fluorophenol (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in dimethylformamide. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.93-2.08 (m, 4H), 2.97-3.07 (m, 2H), 4.05-4.15 (m, 2H), 4.98-5.03 (m, 1H), 7.20-7.24 (m, 2H), 7.33-7.38 (m, 1H), 7.52-7.56 (m, 1H), 8.28 (s, 1H), 8.58 (s, 1H). Mass spectrum MH+=414.

Provenance & Evidence