2,4,6-Trifluorophenol → HCID 57965051, compound

Participants

Reaction Steps

4-[4-(2,4,6-Trifluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure B by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 2,4,6-trifluorophenol (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in dimethylformamide. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.99-2.05 (m, 4H), 2.97-3.05 (m, 2H), 4.07-4.11 (m, 2H), 5.00-5.05 (m, 1H), 7.51-7.55 (m, 2H), 8.53 (s, 1H), 8.60 (s, 1H). Mass spectrum MH+=450.

Provenance & Evidence