Potassium Carbonate → HCID 57964956, compound

Participants

Reaction Steps

4-[4-(4-Trifluoromethoxy-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (12.8 mg, 30%) was prepared using the procedure described for the preparation of Example 41 by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19; 30 mg, 0.09 mmol) with 4-(trifluoromethoxy)-phenol (Avocado Research Chemicals; 16 mg, 0.09 mmol) in the presence of potassium carbonate (27 mg, 0.195 mmol). Mass spectrum MH+=480.

Provenance & Evidence