4-Cyanophenol → HCID 57965002, compound

Participants

Reaction Steps

4-[4-(4-Cyano-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure A by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 4-cyanophenol (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in acetonitrile. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.94-2.04 (m, 4H), 2.95-3.05 (m, 2H), 4.08-4.11 (m, 2H), 4.98-5.04 (m, 1H), 7.58-7.60 (m, 2H), 7.99-8.01 (m, 2H), 8.37 (s, 1H), 8.56 (s, 1H). Mass spectrum MH+=421.

Provenance & Evidence