2-Fluoro-4-hydroxybenzonitrile → HCID 66915304, compound

Participants

Reaction Steps

4-[4-(4-Cyano-3-fluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure B by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 2-fluoro-4-hydroxybenzonitrile (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in dimethylformamide. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.94-2.04 (m, 4H), 2.99-3.07 (m, 2H), 4.08-4.11 (m, 2H), 5.01-5.05 (m, 1H), 7.47-7.50 (m, 1H), 7.75-7.79 (m, 1H), 8.08-8.12 (m, 1H), 8.42 (s, 1H), 8.60 (s, 1H). Mass spectrum MH+=439.

Provenance & Evidence