Formic Acid → 6-(2,2-Difluoroethoxy)-1-(piperidin-4-yl)quinazoline-2,4(1H,3H)-dione

HRID 193166Notes

Reaction equation

HRID 193166 reaction equation
[CH:31]([OH:32])=[O:33].[F:1][CH:2]([CH2:3][O:4][c:5]1[cH:6][c:7]2[c:8](=[O:29])[nH:9][c:10](=[O:28])[n:11]([CH:15]3[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]3)[c:12]2[cH:13][cH:14]1)[F:30]>>[F:1][CH:2]([CH2:3][O:4][c:5]1[cH:6][c:7]2[c:8](=[O:29])[nH:9][c:10](=[O:28])[n:11]([CH:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[c:12]2[cH:13][cH:14]1)[F:30]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 595871251,1-Dimethylethyl 4-[6-(2,2-difluoroethoxy)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carboxylate

Product 1

HCID 866478036-(2,2-Difluoroethoxy)-1-(piperidin-4-yl)quinazoline-2,4(1H,3H)-dione

Sources & evidence

ORD record
ord-5378b7b5a1eb45a68904700798e9be88
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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