3-Fluoro-5-(trifluoromethyl)phenol → HCID 57964986, compound

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Reaction Steps

4-[4-(3-Fluoro-5-trifluoromethyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure B by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 3-fluoro-5-(trifluoromethyl)phenol (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in dimethylformamide. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.94-2.06 (m, 4H), 2.99-3.07 (m, 2H), 4.08-4.11 (m, 2H), 4.99-5.05 (m, 1H), 7.71-7.78 (m, 3H), 8.40 (s, 1H), 8.59 (s, 1H). Mass spectrum MH+=482.

Provenance & Evidence