4'-Hydroxyacetophenone → HCID 57964967, compound

Participants

Reaction Steps

4-[4-(4-Acetyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure B by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 4′-hydroxyacetophenone (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in dimethylformamide. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.94-2.06 (m, 4H), 2.67 (s, 3H), 2.94-3.04 (m, 2H), 4.02-4.10 (m, 2H), 5.00-5.04 (m, 1H), 7.48-7.50 (m, 2H), 8.08-8.10 (m, 1H), 8.32 (s, 1H), 8.55 (s, 1H). Mass spectrum MH+=438.

Provenance & Evidence