1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone → 4-{4-[4-(4-Acetyl-piperazin-1-yl)-phenoxy]-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester

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4-{4-[4-(4-Acetyl-piperazin-1-yl)-phenoxy]-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure B by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 1-acetyl-4-(4-hydroxyphenyl)piperazine (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in dimethylformamide. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.94-2.01 (m, 4H), 2.05 (s, 3H), 2.93-3.02 (m, 2H), 3.10-3.20 (m, 4H), 3.55-3.65 (m, 4H), 4.08-4.11 (m, 2H), 4.96-5.01 (m, 1H), 7.04-7.08 (m, 2H), 7.17-7.20 (m, 2H), 7.95 (s, 1H), 8.53 (s, 1H). Mass spectrum M+Na=544, MH+=522.

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