HCID 57964943, compound → HCID 57964991, compound

Participants

Reaction Steps

A mixture of 4-[4-(1,1-dioxo-1H-1λ6-benzo[b]thiophen-5-yloxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (Example 78; 531 mg, 1.1 mmol) and 10% palladium on carbon (50 mg) in ethyl acetate (40 mL) was stirred under an atmosphere of hydrogen for 3 h. The mixture was then filtered through Celite™ and the filtrate was evaporated and chromatographed, eluting with 50% ethyl acetate/hexanes to give 4-[4-(1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]thiophen-5-yloxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (497 mg, 93%) as a white solid.

Provenance & Evidence