Potassium Carbonate → HCID 178452067, compound

Participants

Reaction Steps

4-{4-[4-(1H-Tetrazol-5-yl)-phenoxy]-pyrazolo[3,4-d]pyrimidin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester (5.3 mg, 13%) was prepared using the procedure described for the preparation of Example 41 by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19; 30 mg, 0.09 mmol) with 5-(4-hydroxyphenyl)tetrazole (Biofine International Inc., Blaine, Wash., USA; 15 mg, 0.09 mmol) in the presence of potassium carbonate (27 mg, 0.195 mmol).

Provenance & Evidence