Potassium Carbonate → HCID 57964938, compound

Participants

Reaction Steps

4-[4-(2,6-Dimethyl-pyridin-3-yloxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (41 mg, 65%) was prepared using the procedure described for the preparation of Example 96, by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19; 50 mg, 0.15 mmol) with 2,6-dimethyl-3-hydroxypyridine (Apollo Scientific Ltd., Stockport, Cheshire, UK; 16 mg) in the presence of potassium carbonate (27 mg, 0.19 mmol) in dimethylformamide (2 mL). Mass spectrum (ES) MH+=425. HRMS Calcd. for C22H29N6O3 (MH+): 425.2296. Found: 425.2294.

Provenance & Evidence