Potassium Carbonate → HCID 57964930, compound

Participants

Reaction Steps

4-[4-(5-Chloro-pyridin-3-yloxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (10 mg, 16%) was prepared using the procedure described for the preparation of Example 96, by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19; 50 mg, 0.15 mmol) with 5-chloro-3-pyridinol (Aldrich Chemical Company, Inc., Milwaukee, Wis., USA 25 mg, 0.19 mmol) in the presence of potassium carbonate (27 mg, 0.19 mmol) in dimethylformamide (2 mL). Mass spectrum (ES) MH+=431. HRMS Calcd. for C20H24ClN6O3 (MH+): 431.1593. Found: 431.1593.

Provenance & Evidence