Potassium Carbonate → HCID 57964997, compound

Participants

Reaction Steps

4-[4-(6-Ethyl-2-methyl-pyrimidin-4-yloxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (10 mg, 13%) was prepared using the procedure described for the preparation of Example 41 by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19; 60 mg, 0.18 mmol) with 4-ethyl-6-hydroxy-2-methylpyrimidine (Synchem Inc., Des Plaines, Ill., USA; 25 mg, 0.18 mmol) in the presence of potassium carbonate (54 mg, 0.39 mmol). Mass spectrum MH+=440.

Provenance & Evidence