2,2,2-Trichloroethyl chloroformate → HCID 57964893, compound

Participants

Reaction Steps

4-[4-(4-Methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester was prepared according to General Procedure E by the reaction of 4-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoro-acetate salt (Intermediate 27) with 2,2,2-trichloroethyl chloroformate (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA). 1H NMR (400 MHz, DMSO-d6) δ 1.96-2.08 (m, 4H), 3.30 (methyl sulfonyl and water peak), 4.11-4.20 (m, 2H), 4.86-4.89 (m, 2H), 5.05-5.10 (m, 1H), 7.59-7.62 (m, 2H), 8.03-8.05 (m, 2H), 8.36 (s, 1H), 8.54 (s, 1H). Mass spectrum MH+=548.

Provenance & Evidence