Potassium Carbonate → HCID 86636109, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-methanesulfonyl-phenol (available from Acros Organics, Geel, Belgium; 24 mg, 0.14 mmol), 4-chloro-1-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidine (Intermediate 22; 40 mg, 0.11 mmol) and potassium carbonate (19 mg, 0.14 mmol) in anhydrous DMF (2 mL) was heated in a Biotage Optimizer microwave at 180° C. for 10 min. The mixture was cooled and filtered through Celite, concentrated and held under vacuum. The residue was purified by flash column chromatography eluting with 0-3% methanol/dichloromethane to give 4-(4-methanesulfonyl-phenoxy-1-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidine (40 mg, 72%). Mass spectrum (ES) MH+=483.5.

Provenance & Evidence