Potassium Carbonate → 1-[4-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-cyclohexyl]-4-(2-methyl-pyridin-3-yloxy)-1H-pyrazolo[3,4-d]pyrimidine

Participants

Reaction Steps

1-[4-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-cyclohexyl]-4-(2-methyl-pyridin-3-yloxy)-1H-pyrazolo[3,4-d]pyrimidine (60 mg, 76%) was prepared using the procedure described for the preparation of Example 41 by the reaction of 4-chloro-1-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidine (Intermediate 23; 130 mg, 0.375 mmol) with 3-hydroxy-2-methylpyridine (Aldrich Chemical Company, Inc., Milwaukee, Wis., USA; 42 mg, 0.385 mmol) in the presence of potassium carbonate (114 mg, 0.825 mmol). The compound was purified by column chromatography, eluting with 5% methanol/dichloromethane. Mass spectrum MH+=420.

Provenance & Evidence