Cyclobutanecarbonyl chloride → HCID 57964902, compound

Participants

Reaction Steps

Cyclobutyl-{4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-methanone was prepared according to General Procedure I by the reaction of 4-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoroacetate salt (Intermediate 27) with cyclobutanecarbonyl chloride (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA). 1H NMR (400 MHz, DMSO-d6) δ 1.74-2.21 (m, 10H), 2.82-2.87 (m, 1H), 3.30 (methyl sulfonyl and water peak), 3.84-3.87 (m, 1H), 4.49-4.52 (m, 1H), 5.06-5.08 (m, 1H), 7.62-7.65 (m, 2H), 8.05-8.07 (m, 2H), 8.38 (s, 1H), 8.57 (s, 1H). Mass spectrum MH+=456, M+Na=478.

Provenance & Evidence