Benzoyl chloride → HCID 57964935, compound

Participants

Reaction Steps

{4-[4-(4-Methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-phenylmethanone was prepared according to General Procedure I by the reaction of 4-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoroacetate salt (Intermediate F1) with benzoyl chloride (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA). 1H NMR (400 MHz, DMSO-d6) δ 1.98-2.10 (m, 4H), 3.30 (methyl sulfonyl and water peak), 3.70-3.75 (m, 1H), 4.58-4.63 (m, 1H), 5.14-5.17 (m, 1H), 7.42-7.52 (m, 5H), 7.63-7.65 (m, 2H), 8.05-8.07 (m, 2H), 8.41 (s, 1H), 8.58 (s, 1H). Mass spectrum MH+=478.

Provenance & Evidence