3,5-Dichlorobenzoyl chloride → HCID 57964881, compound

Participants

Reaction Steps

(3,5-Dichloro-phenyl)-{4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-methanone was prepared according to General Procedure H by the reaction of 4-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoroacetate salt (Intermediate 27) with 3,5-dichlorobenzoyl chloride (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA). 1H NMR (400 MHz, DMSO-d6) δ 2.02-2.10 (m, 4H), 3.12-3.18 (m, 1H), 3.30 (methyl sulfonyl and water peak), 3.62-3.68 (m, 1H), 4.54-4.60 (m, 1H), 5.10-5.16 (m, 1H), 7.54-7.55 (m, 2H), 7.63-7.65 (m, 2H), 7.72-7.73 (m, 1H), 8.05-8.07 (m, 2H), 8.41 (s, 1H), 8.58 (s, 1H). Mass spectrum MH+=546, M+Na=478.

Provenance & Evidence