p-Anisoyl chloride → HCID 57964976, compound

HRID 1931754Notes

Reaction equation

HRID 1931754 reaction equation
FC(F)(F)C(O)=O.[CH3:8][S:9]([C:12]1[CH:33]=[CH:32][C:15]([O:16][C:17]2[N:22]=[CH:21][N:20]=[C:19]3[N:23]([CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[N:24]=[CH:25][C:18]=23)=[CH:14][CH:13]=1)(=[O:11])=[O:10].[C:34](Cl)(=[O:43])[C:35]1[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=1>>[CH3:8][S:9]([C:12]1[CH:13]=[CH:14][C:15]([O:16][C:17]2[N:22]=[CH:21][N:20]=[C:19]3[N:23]([CH:26]4[CH2:27][CH2:28][N:29]([C:34]([C:35]5[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=5)=[O:43])[CH2:30][CH2:31]4)[N:24]=[CH:25][C:18]=23)=[CH:32][CH:33]=1)(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 669153264-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoroacetate salt2×

Product 1

HCID 57964976HCID 57964976, compound

Procedure

{4-[4-(4-Methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-(4-methoxy-phenyl)-methanone was prepared according to General Procedure I by the reaction of 4-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoroacetate salt (Intermediate 25) with p-anisoyl chloride (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA). 1H NMR (400 MHz, DMSO-d6) δ 2.04-2.13 (m, 4H), 3.30 (methyl sulfonyl and water peak), 3.80 (m, 3H), 5.10-5.15 (m, 1H), 7.00-7.02 (m, 2H), 7.41-7.43 (m, 2H), 7.62-7.65 (m, 2H), 8.05-8.07 (m, 2H), 8.41 (s, 1H), 8.57 (s, 1H). Mass spectrum MH+=508.

Sources & evidence

ORD record
ord-948a4b9fa53c4f87b184e0e00e1feb77
Source dataset
uspto-grants-2012_05
Patent number
US08188098B2

Reaction notes

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