Triethylamine → HCID 57965013, compound

Participants

Reaction Steps

4-(4-Methanesulfonyl-phenoxy)-1-[1-(4-trifluoromethyl-benzyl)-piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidine was prepared according to General Procedure H by the reaction 4-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoroacetate salt (Intermediate 27) with 4-(trifluoromethyl)benzaldehyde (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA), triethylamine, and sodium triacetoxyborohydride in 1,2-dichloroethane. 1H NMR (400 MHz, DMSO-d6) δ 1.95-1.99 (m, 2H), 2.20-2.33 (m, 4H), 2.93-2.97 (m, 2H), 3.30 (methyl sulfonyl and water peak), 3.66 (s, 2H), 4.77-4.83 (m, 1H), 7.58-7.64 (m, 4H), 7.70-7.72 (m, 2H), 8.04-8.07 (m, 2H), 8.37 (s, 1H), 8.57 (s, 1H). Mass spectrum MH+=532.

Provenance & Evidence