Triethylamine → HCID 57965054, compound

Participants

Reaction Steps

4-(4-Methanesulfonyl-phenoxy)-1-[1-(4-methoxy-benzyl)-piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidine was prepared according to General Procedure H by the reaction of 4-(4-methanesulfonyl-phenoxy)-1-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidine trifluoroacetate salt (Intermediate 27) with p-anisaldehyde (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA), triethylamine, and sodium triacetoxyborohydride in 1,2-dichloroethane. 1H NMR (400 MHz, DMSO-d6) δ 1.91-1.94 (m, 2H), 2.13-2.23 (m, 4H), 2.93-2.97 (m, 2H), 3.30 (methyl sulfonyl and water peak), 3.47 (s, 2H), 3.74 (s, 3H), 4.74-4.80 (m, 1H), 6.89-6.91 (m, 2H), 7.24-7.26 (m, 2H), 7.62-7.64 (m, 2H), 8.04-8.06 (m, 2H), 8.36 (s, 1H), 8.55 (s, 1H). Mass spectrum MH+=494.

Provenance & Evidence