HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → 3-(3-Chloro-5-fluorophenyl)-1-ethylpyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-(3-Chloro-5-fluorophenyl)pyrrolidin-3-ol | HCID 68515653 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(3-Chloro-5-fluorophenyl)-1-ethylpyrrolidin-3-ol | HCID 25145777 | — |
Reaction Steps
Preparation according to Example 8: 3-(3-chloro-5-fluorophenyl)pyrrolidin-3-ol (0.30 g, 1.4 mmol), acetonitrile (20 mL), sodium carbonate (0.19 g, 3.5 mmol), iodoethane (0.22 g, 1.4 mmol). Yield: 0.17 g. The amine was converted to the oxalic acid salt and recrystallized from ethanol/diethyl ether/diisopropyl ether: M.p. 169-170° C.; MS m/z (relative intensity, 70 eV) 243 (M+, 8), 228 (7), 157 (7), 129 (7), 72 (30), 71 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188301B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e99ca8bffa8041f4b6f9fc68a720969a |
| Source note | uspto-grants-2012_05 |