HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 25143668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | HCID 63585886 | HCID 63585886 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | HCID 25143668 | HCID 25143668 | — |
Reaction Steps
Preparation according to Example 11: 3-(3,5-difluorophenyl)pyrrolidin-3-ol (0.125 g, 0.628 mmol), formic acid (1.82 mL), aqueous formaldehyde (40%, 1.63 mL). 65° C.; over night. The amine was converted to the oxalic acid salt and recrystallized from methanol/diethyl ether (0.126 g). M.p. 159-162° C.; MS m/z (relative intensity, 70 eV) 213 (M+, 27), 141 (13), 113 (15), 58 (32), 57 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188301B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-079798f96dac427e89c32eb7a4994799 |
| Source note | uspto-grants-2012_05 |