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Potassium Carbonate → HCID 25143671、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Iodopropane | HCID 33643 | — |
| 反応物 | 3-(3-Chloro-4-fluorophenyl)pyrrolidin-3-ol | HCID 68517837 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | HCID 25143671 | HCID 25143671 | — |
反応手順
Preparation according to Example 22: 3-(3-chloro-4-fluorophenyl)pyrrolidin-3-ol (0.8 g, 3.72 mmol), potassium carbonate (1.03 g, 7.45 mmol), iodopropane (0.83 mg, 4.86 mmol), acetonitrile (20 mL). Purification by flash chromatography on silica gel (ethyl acetate/methanol, 1:1 to 0:1). Yield: 520 mg. The amine was converted to the fumaric acid salt and recrystallized from ethanol/diethyl ether: M.p. 157.9° C.; MS m/z (relative intensity, 70 eV) 257 (M+, 8), 228 (bp), 198 (30), 157 (15), 84 (88).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08188301B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-5d4bcd40cb454c579ba1b32305ac27ff |
| 出典メモ | uspto-grants-2012_05 |