Morpholine → (+)-3-(2,3-Difluorophenyl)-1-propylpyrrolidin-3-OL

Participants

Reaction Steps

Preparation according to Example 34: (−)-1-benzyl-3-(2,3-difluorophenyl)pyrrolidin-3-ol (0.40 g, 1.38 mmol), dimethyl formamide (3 mL), iodopropane (1.35 mL, 13.8 mmol) and morpholine (2 mL). Purification by HPLC on Waters OBD C18, 5 μm (MeOH/33 mM NH3, 40:60 to 60:40). Yield: 0.174 g. [α]D=−22.1° (methanol). The amine was converted to the fumaric acid salt and recrystallized from methanol/diethyl ether/diisopropyl ether: M.p. 97-100° C.; MS m/z (relative intensity, 70 eV) 241 (M+, 10), 212, (bp), 182 (34), 84 (53), 57 (14).

Provenance & Evidence