Oxalic Acid → HCID 25143814, compound

Participants

Reaction Steps

Preparation according to Example 51. Enantiomer E1 of 3-(2,3-difluorophenyl)-pyrrolidin-3-ol (0.15 g, 0.77 mmol), acetonitrile (6 mL), potassium carbonate (0.21 g, 1.55 mmol), n-butylbromid, (0.08 mL, 0.77). Flash chromatography on silica gel (Ethyl acetate/methanol, 7:1). Yield: 0.085 g. [α]D=+24.8°; The amine was converted to the oxalic acid salt and recrystallized from ethanol/diisopropyl ether; M.p. 157-158° C.; MS m/z (relative intensity, 70 eV) 255 (M+, 7), 212 (bp), 98 (52), 57 (40), 182 (37), 127 (16).

Provenance & Evidence