HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1931863Generated: November 2, 2026
Tert-butyl 3-oxopyrrolidine-1-carboxylate → HCID 67403422, compound
https://huagongshe.com/reaction/1931863
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tert-butyl 3-oxopyrrolidine-1-carboxylate | HCID 471360 | — |
| Reactant | 1-Bromo-2,3-difluorobenzene | HCID 2733260 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 67403422 | HCID 67403422 | — |
Reaction Steps
Preparation according to Preparation 23: 1-bromo-2,3-difluorobenzene (3.12 g, 16.2 mmol), dry diethyl ether (30 mL), N-butyl lithium (2.5 M, 6.5 mL, 16.2 mmol), 1-N-boc-3-pyrrolidinone (2.0 g, 10.8 mmol). Stirred 2 h at −78° C. before addition, and 1 h at ambient temperature after addition of 1-N-boc-3-pyrrolidinone. Yield: 1.72 g. MS m/z (rel. intensity, 70 eV) 299 (M+, 1), 243 (46), 226 (38), 198 (68), 57 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08188301B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-3f8c13eb3fcd4cfaa27ac39ebcf521f3 |
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| Source note | uspto-grants-2012_05 |
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