Trifluoroacetic acid → HCID 68516033, compound

Participants

Reaction Steps

Preparation according to Preparation 2: tert-butyl 3-(3,5-dichlorophenyl)-3-hydroxypyrrolidin-1-carboxylate (1.3 g, 3.9 mmol), dichloromethane (10 mL) and trifluoroacetic acid (3 mL). Stirred for 1 h. Purification by HPLC on Waters OBD C18, 5 μm (MeOH/33 mM NH3, 20:80 to 40:60). Yield: 0.57 g. MS m/z (rel. intensity, 70 eV) 233 (M+, 64), 231 (M+, bp), 145 (56), 111 (55), 75 (72).

Provenance & Evidence