Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 3-(3,4-Difluorophenyl)pyrrolidin-3-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Tert-butyl 3-(3,4-difluorophenyl)-3-hydroxypyrrolidine-1-carboxylate | HCID 67405004 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(3,4-Difluorophenyl)pyrrolidin-3-ol | HCID 63586972 | — |
반응 단계
Preparation according to Preparation 2: tert-Butyl 3-(3,4-difluorophenyl)-3-hydroxy-pyrrolidin-1-carboxylate (2.6 g, 8.69 mmol), dichloromethane (3 mL) and trifluoroacetic acid (3 mL). Stirred for 4 h. Yield: 1.32 g. MS m/z (relative intensity, 70 eV) 199 (M+, 876), 141 (bp), 127 (58), 113 (99), 63 (55).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08188301B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-dad29534054048a6bf42ece514e1496f |
| 출처 메모 | uspto-grants-2012_05 |