Triethylsilane → HCID 63585886, compound

Participants

Reaction Steps

A mixture of (−)-1-benzyl-3-(3,5-difluorophenyl)pyrrolidin-3-ol (2.73 g, 9.44 mmol), methanol (20 mL) and palladium on carbon (500 mg) was purged with nitrogen. Triethyl silane (15.09 mL, 94.4 mmol) was added drop wise over 3 h and the mixture was stirred at ambient temperature for 24 h. The mixture was filtrated over celite, evaporated and purified by flash chromatography on silica gel (ethyl acetate/methanol/triethylamine, 1:0 to 0:4:1) to give the title compound (1.4 g). MS m/z (relative intensity, 70 eV) 199 (M+, bp), 141, (50), 127 (58), 114 (50), 113 (71).

Provenance & Evidence