反应详情

温度

25 °C

A mixture of 2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-5,5,5-trifluoro-pentanoic acid methyl ester (1.02 g, 2.70 mmol) in a 1:1 solution of tetrahydrofuran:water (30 mL) was treated with lithium hydroxide monohydrate (270 mg, 5.40 mmol). The mixture was stirred for 2 h at 25° C. After such time, the mixture was concentrated in vacuo to remove the tetrahydrofuran, diluted with water and the pH adjusted to pH=5 with 1N aqueous hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford 2-[4-(2-chloro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-5,5,5-trifluoro-pentanoic acid (766 mg, 78%) as a cream colored solid: HR-ES-MS m/z calculated for C15H13NO4ClF3 [M+H]+ 364.0558, observed 364.0557.

1. concentrationAfter such time, the mixture was concentrated in vacuo
2. customto remove the tetrahydrofuran
3. additiondiluted with water
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layer was dried over sodium sulfate
6. concentrationconcentrated in vacuo