HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[2-(t-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-4-pyrimidineamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Reactant | tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 22061016 | — |
| Product | 2-chloro-5-fluoro-N4-[2-(t-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-4-pyrimidineamine | HCID 22060606 | — |
Reaction Steps
In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and 7-amino-2-(t-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline were reacted to provide 2-chloro-5-fluoro-N4-[2-(t-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-4-pyrimidineamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188276B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a69ed78e63e24fa985c4ff0215565204 |
| Source note | uspto-grants-2012_05 |