2-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamine → HCID 66759428, compound

HRID 1932082Notes

Reaction equation

HRID 1932082 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]3[O:15][CH2:16][CH2:17][O:18][C:11]=3[CH:10]=2)[C:5]([F:19])=[CH:4][N:3]=1.[NH2:20][CH:21]=[C:22]1[CH:26]=[CH:25][O:24][CH2:23]1>>[CH2:17]1[CH2:16][O:15][C:12]2[CH:13]=[CH:14][C:9]([NH:8][C:6]3[C:5]([F:19])=[CH:4][N:3]=[C:2]([N:20]=[CH:21][C:22]4[CH:26]=[CH:25][O:24][CH:23]=4)[N:7]=3)=[CH:10][C:11]=2[O:18]1

Participants

3

Reactant 2

HCID 220603622-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamineHCID 667589033-Aminomethylenefurane

Product 1

HCID 66759428HCID 66759428, compound

Procedure

In like manner to the preparation of N4-(3-aminophenyl)-N2-[2-(methoxycarbonyl)-benzofurane-5-yl]-5-fluoro-2,4-pyrimidinediamine, 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine and 3-aminomethylenefurane were reacted to give N4-(3,4-ethylenedioxyphenyl)-N2-(3-furanylmethylene)-5-fluoro-2,4-pyrimidinediamine. LCMS: rct. time: 19.99 min.; purity: 88.4%; MS (m/e): 343.07 (MH+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-05811b2b652349fe979458e449bfc526
Source dataset
uspto-grants-2012_05
Patent number
US08188276B2

Reaction notes

Loading…