p-Fluorophenethylamine → 249624-75-7

HRID 1932305Notes

Reaction equation

[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[C:11](Cl)(=O)[CH3:12]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8][CH:11]2[CH3:12])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 4653p-Fluorophenethylamine

HCID 6367Acetyl chloride

Product 1

HCID 12991370249624-75-7

Procedure

In accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21, except for using 4-fluorophenethylamine and acetyl chloride, 7-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline was obtained. In accordance with the same procedures as in Preparation 20, the titled compound was obtained as pale yellow oil. (Yield: 69%) The product was used in the subsequent step without further purification.

Workup

customIn accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21

Sources & evidence

ORD record: ord-56613816c0704194a17e10d45533ec57
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188114B2

Reaction notes

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